… binding and assembly of the viral matrix layer. We found that when VP40 binds PI(4,5)P 2 ,
VP40 … Together, this work characterizes the molecular basis of PI(4,5)P 2 binding by VP40, …

… that forms a shell beneath the lipid bilayer in virions and virus-like particles (VLPs). VP40
is required for virus assembly and budding from the host cell plasma membrane. VP40 is a …

… ability, we evaluated the effects of G198A, G198R, G198D, and G201R on PS and PI(4,5)P
2 binding using surface plasmon resonance (SPR) and a large multilamellar vesicle (MLV) …

… membranes in order to assemble and bud into new virions. A … VP40 co-localizes with PS
binding protein on the plasma … A second binding site distinct from the PI (4,5)P2 binding site of …

… the Ebola virus (EBOV) matrix protein VP40 oligomeric forms … and PI(4,5)P 2 and can assemble
into (6) oligomers via CTD–… The phosphorylation of eVP40 was found to be modulated by …

… VP40, as it is for interactions with viral matrix proteins of other … budding in the presence of
Nedd4 is most likely modulated by … access to its binding site. The relevance of Alix on EBOV …

… The Ebola virus matrix protein VP40 clusters … requires both PS and PI(4,5)P 2 for efficient
membrane binding and … a filovirus matrix protein modulating the organization of PS within the …

… in the plasma membrane affects VP40 assembly and budding. These studies … budding of
the Ebola virus from the plasma membrane. For instance, therapeutic agents that can modulate …

… of PS concentration on VP40 assembly, oligomerization and … both PS and PI(4,5)P 2 for
efficient membrane binding and … of a filovirus matrix protein modulating the organization of PS …

… for the treatment of Marburg or Ebola virus infection. In two … Whereas VP40 and VP24
coordinate assembly and budding … core that bears the receptor-binding site. GP 2 is the …